Breadcrumbs ![Why This Ingredient Could Give You Your Best Skin Yet](https://media.sheerluxe.com/mRooldZtIdTK4oRFBXBVh_Jca8o=/800x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fsl-site-assets-240826-thumb-hero-pdrn-beauty.jpg) Image: AI Generated [Skincare](/beauty/skincare) / 24 August 2026 # Why This Ingredient Could Give You Your Best Skin Yet PDRN is everywhere right now – from K-beauty serums and masks to injectable skin boosters. Known for its hydrating, soothing properties, it’s quickly become one of beauty’s biggest buzzwords. Here, the experts explain how the ingredient works, what it can do for your skin and how to incorporate it into your routine… ByOrin Carlin / [ Save To My Favourites ](/user/login?destination=/markdownify/node/53813) Image: AI Generated All products on this page have been selected by our editorial team, however we may make commission on some products. ### What Is It? PDRN is fast becoming one of skincare’s most talked-about ingredients but the science behind it has been around for years. “PDRN stands for polydeoxyribonucleotide. These are short DNA fragments traditionally and most often derived from salmon,” explains [Dr Christine Hall](https://www.instagram.com/drchristinehall/), aesthetic doctor & K-beauty expert. “It has existed for years in Korea and is sold in Korean pharmacies for healing and compromised skin, and we are now seeing more PDRN appearing in skincare in the West in the form of serums, creams and masks.” “Polynucleotides are the injectable form which have been around for much longer and have more evidence behind them. Polynucleotides are also DNA fragments which have slightly longer chains and were originally used in regenerative medicine, particularly for wound healing, burns and tissue repair. It was in 2014 that Korea launched the first injectable treatment designed for aesthetic medicine called Rejuran.” ### How Does It Work? “When injected, polynucleotides can reach the deeper layers of the skin and stimulate fibroblasts, which are the cells involved in producing collagen, as well as supporting the skin’s repair processes. Topically, it is a bit different. PDRN is quite a large molecule, so it is unlikely to penetrate the skin deeply enough to have the same effect as injected PDRN. What it can do is help to hydrate and soothe the skin, reduce inflammation and support the skin while it is repairing itself. So I would not expect a PDRN serum to stimulate collagen in the same way that an injectable treatment can. The effects are much more surface level.” *– Christine* ### How Does It Compare To Injectable Treatments? “Injectable PDRN, often referred to as a polynucleotide treatment or skin booster, is injected directly into the skin. That means it can get much closer to the cells and structures where it is able to have its regenerative effects. This is also where we have more of the clinical research. With a serum or cream, PDRN has to get through the skin barrier and the molecule is simply too large to penetrate very deeply. So you are not going to get the same result from a topical product as you would from an injectable. That said, topical PDRN can still be useful. Think of it more as something that can help keep the skin hydrated, calm and supported, rather than something that is going to produce the same kind of structural changes you might see from an injectable treatment.” *– Christine* ### What Are The Benefits? “Topical PDRN gives your skin that immediate surge of hydration, visibly plumping up expression lines and leaving you with a smooth, radiant glow. Beyond that quick refresh, it works beneath the surface to strengthen your barrier and support natural collagen, helping firm things up. If your skin is feeling a bit dull, dehydrated, or starting to show expression lines at rest and uneven texture, PDRN is great to add to your routine. The best part? Topical formulas are super gentle and safe for pretty much every skin type. Just keep in mind that while it won’t give you the instant, dramatic volume bump of an in-clinic injectable, it builds up beautiful, healthy results over time as you stick with it.” – [*Sophie Anne Perry*](https://www.instagram.com/sophieanneperry_/)*, facialist* ### What Are The Different Types? “Traditional PDRN is usually derived from salmon and that is the form that has been studied the most, interestingly the DNA of a salmon is also very structurally close to that of a human. If you have a fish allergy, are vegan or vegetarian, or simply prefer not to use animal-derived ingredients, you may want to look for an alternative. There are now plant-based and vegan versions available, which are designed to offer similar benefits. The research around these is newer, so there’s not enough evidence to say these perform exactly the same as salmon-derived PDRN.” *– Christine* ### What’s Worth Paying Attention To? “When choosing a PDRN product, pay attention to the formula’s molecular size and its supporting ingredients. Opt for micro-sized or bio-fermented PDRN, which is specifically engineered to sink right into the skin rather than sitting on top. It works even better when paired with heavy-hitting complementary actives, like hyaluronic acid to pull hydration deep into the skin, alongside niacinamide to help even out skin tone and boost firmness.” *– Sophie* *Follow* [@DRCHRISTINEHALL](https://www.instagram.com/drchristinehall/) *&* [@SOPHIEANNEPERRY\_](https://www.instagram.com/sophieanneperry_/) [Skip to the rest of this article](#sidebar-bottom) ## We think you might like ![A Beauty Tastemaker’s Morning Must-Haves](https://media.sheerluxe.com/XZiqsAIh31dmHJcDETo9TmtQ1X0=/600x800/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fsl-site-assets-240826-thumb-cassandra-grey.jpg) [Beauty](/beauty) / 24 August 2026 [## A Beauty Tastemaker’s Morning Must-Haves ](/beauty/a-beauty-tastemakers-morning-must-haves) ![Alex Steinherr's Need-To-Know Beauty Experts & Addresses](https://media.sheerluxe.com/cu_G9cPTkQNk0w_uMmyYgVkLP84=/600x800/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fsl-site-assets-210826-thumb-alex-s-london-beauty-hotspots.jpg) [Beauty](/beauty) / 21 August 2026 [## Alex Steinherr's Need-To-Know Beauty Experts & Addresses ](/beauty/alex-steinherrs-need-to-know-beauty-experts-addresses) ![The Affordable Serum Everyone’s Talking About](https://media.sheerluxe.com/tEKgKrVyjVvnFTvWefq4XZ3uZfE=/600x800/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fsl-site-assets-210826-thumb-ms-beauty-commercial.jpg) [Skincare](/beauty/skincare) / 21 August 2026 [## The Affordable Serum Everyone’s Talking About ](/beauty/skincare/the-affordable-serum-everyones-talking-about) ## In case you missed it ![ Are Celebrity Weddings Getting Out Of Control?](https://media.sheerluxe.com/BKL980uqY9a-r5jzRaE9YGhA0rE=/860x492/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fsl-pod-200826-1920.jpg) ![ Are Celebrity Weddings Getting Out Of Control?](https://media.sheerluxe.com/atsWTKoD_Q1j8H48XKRXfz5uzhI=/400x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fsl-pod-200826-1200.jpg "Are Celebrity Weddings Getting Out Of Control? ") [SheerLuxe Podcast](/video/sheerluxe-podcast) / 21 August 2026 [## Are Celebrity Weddings Getting Out Of Control? ](/video/sheerluxe-podcast/are-celebrity-weddings-getting-out-of-control) --- ## SHOP THE SKINCARE EDIT ![PDRN Essence 100 from VT Cosmetics](https://media.sheerluxe.com/38byDn0wUtN8T8PaNTTgtjwIGX4=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fvt-cosmetics-pdrn-essence-100.png) [#### PDRN Essence 100](https://www.awin1.com/cread.php?awinmid=2082&awinaffid=69421&platform=dl&ued=https%3A%2F%2Fwww.lookfantastic.com%2Fp%2Fvt-cosmetics-pdrn-essence-100%2F17620559%2F) ##### VT Cosmetics, £27.20 *(was £34)* [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") ![Revitalift 1.5% Hyaluronic Acid Serum from L'Oréal Paris](https://media.sheerluxe.com/t7egiZ9uRie3og50FMGTIHnrrlk=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Floreal-paris-revitalift-filler-hyaluronic-pdrn-anti-wrinkle-plumping-serum_0.png) [#### Revitalift 1.5% Hyaluronic Acid Serum](https://www.awin1.com/cread.php?awinmid=2041&awinaffid=69421&platform=dl&ued=https%3A%2F%2Fwww.boots.com%2Floreal-paris-revitalift-filler-serum-30ml-10274580) ##### L'Oréal Paris, £31.99 [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") ![Exo-PDRN Prismatic+ from Medik8](https://media.sheerluxe.com/Jmw8OdRPBk8GSC8MAHCq0jPfpcU=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fmedik8-exo-pdrn-serum.png) [#### Exo-PDRN Prismatic+](https://www.awin1.com/cread.php?awinmid=99011&awinaffid=69421&platform=dl&ued=https%3A%2F%2Fwww.medik8.com%2Fproducts%2Fexo-pdrn-prismatic) ##### Medik8, £79 [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") ![Advanced PDRN Rejuvenating Cream from Dr.Reju-All](https://media.sheerluxe.com/Zif_zSZRYwXp9dvQx9aPORJfWxs=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fdrreju-all-all-advanced-pdrn-rejuvenating-cream-20ml-offer-drreju-all-all-advanced-pdrn-rejuvenating.png) [#### Advanced PDRN Rejuvenating Cream](https://www.awin1.com/cread.php?awinmid=2041&awinaffid=69421&platform=dl&ued=https%3A%2F%2Fwww.boots.com%2Fdr-rejuall-all-advanced-pdrn-rejuvenating-cream-20ml-10382170) ##### Dr.Reju-All, £25.90 [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") ![PDRN Hyaluronic Acid Hydrating Capsule Mist from Anua](https://media.sheerluxe.com/zD90dszRoWGz2NgUIgcF8zEPpA4=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fanua-exclusive-pdrn-hyaluronic-acid-hydrating-capsule-mist.png) [#### PDRN Hyaluronic Acid Hydrating Capsule Mist](https://www.awin1.com/cread.php?awinmid=2082&awinaffid=69421&platform=dl&ued=https%3A%2F%2Fwww.lookfantastic.com%2Fp%2Fanua-exclusive-pdrn-hyaluronic-acid-hydrating-capsule-mist-30ml%2F17751129%2F) ##### Anua, £11.20 *(was £14)* [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") ![Hydrating PDRN Serum from Boots](https://media.sheerluxe.com/6chZYGJUU6_NX19M10xx7wNk154=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fboots-hydrating-pdrn-serum.png) [#### Hydrating PDRN Serum](https://www.awin1.com/cread.php?awinmid=2041&awinaffid=69421&platform=dl&ued=https%3A%2F%2Fwww.boots.com%2Fboots-pdrn-serum-30ml-10383077) ##### Boots, £8 [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") ![Capture Hyalushot Advanced from Dior](https://media.sheerluxe.com/j74CxLMEp6p79Ae30L9il91-kGE=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fdior-capture-pdrn-shot.png) [#### Capture Hyalushot Advanced](https://click.linksynergy.com/deeplink?id=etT1jgERWYw&mid=47916&murl=https%3A%2F%2Fwww.dior.com%2Fen_gb%2Fbeauty%2Fproducts%2Fdior-capture-hyalushot-advanced-Y0000262.html) ##### Dior, £72 [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") ![PDRN Lifting Pad from Mediheal](https://media.sheerluxe.com/w3_s-47XngpzLK5DGldbqMior7k=/600x0/smart/https%3A%2F%2Fsheerluxe.com%2Fsites%2Fsheerluxe%2Ffiles%2Farticles%2F2026%2F08%2Fmediheal-pdrn-lifting-pad.png) [#### PDRN Lifting Pad](https://www.awin1.com/cread.php?awinmid=2041&awinaffid=69421&platform=dl&ued=https%3A%2F%2Fwww.boots.com%2Fmediheal-pdrn-lifting-pad-170ml-100-pads-10382518) ##### Mediheal, £22 [ Flag this item ](/user/login?destination=/markdownify/node/53813 "Add product to my favourites") [Skip to the rest of this article](#sidebar-bottom) ## 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