The Hormone Hack You Could Be Missing Out On

Creatine’s role in physical performance is well documented but its connection to a metabolic process called methylation is what people are paying attention to. Methylation is critical to hundreds of essential functions in the human body, including hormone regulation, DNA repair and energy metabolism. Now seen as one of the body’s most important biochemical processes, we also know our bodies use a significant part of its methylation capacity to produce natural creatine. So by supplementing with creatine, those resources could be redirected to other important functions like mood regulation and detoxification.

The redirection of methylation capacity becomes particularly relevant for women, especially during perimenopause and menopause when hormonal changes can demand more from our bodies and systems. Oestrogen metabolism – the process by which the body processes and clears oestrogen – relies on an enzyme called COMT that requires methylation (a fundamental biochemical process) to function. When methylation capacity is under pressure, that clearance process can become less efficient. By reducing the methylation demand that creatine synthesis places on the body, supplementing creatine may help free up capacity for processes like this. Overall, it supports more balanced energy, mood and cognitive function."